In this review
In this review
Older dog showing the classic signs of joint discomfort?
- Weak hind legs?
- Slow to stand & lay down?
- Less interest in play?
If you’re anything like us you’ll do everything to keep them happy, healthy, and mobile. Fortunately, joint supplements promote:
- Cartilage health to keep joints strong and flexible.
- Mobility and reduce discomfort.
- Regular activity to maintain overall health and happiness.
But with countless options at Petco, Chewy, and Amazon - what works? And what’s actually the best for your dog?
Our staff (parents to dozens of dogs) with the help of Dr. Joseph Menicucci (DVM) - practicing Veterinarian (no affiliation to the brands tested) - evaluated joint supplements on ingredients, taste, dosage, and formulation. After comparing dozens of products, we tested our top pick in real-world use with one of our staff’s older dogs. We’re excited to share our Top Picks of 2025 - all Manufactured in the USA.
A Note on Manufactured in the USA
For our loved ones (including our dogs!), choosing USA-manufactured supplements is about quality and reliability. All of the reviewed supplements are Manufactured in the USA, with globally-sourced ingredients. That means they are:
Health & Safety: Certified by the National Animal Supplement Council (NASC),undergoing rigorous third-party safety testing every 2 years.1
Traceability & Testing: Follow Good Manufacturing Practices (GMP) and test for purity, potency, and contaminants.2
Giving Back: Support American manufacturing and farming; 2020 study found that the domestic pet food industry generates over $7B in yearly revenue for US-based farmers and workers.3
How These USA-Manufactured Dog Joint Supplements Compare:
Overall Rating:
Ingredients and Dosing:
#1 Wuffes Advanced Hip & Joint Support: Best Overall Dog Joint Supplement
Rating: 9.7/10
Optimal Formulation & Dosing plus Best Taste
Wuffes stood out in every part of our testing, from ingredients, to dosing, to real-world benefits.
Over six weeks, our tester, Emily, evaluated Wuffes with her 10-year-old dog Momo. After, Emily said Momo had “transformed back to her younger, happier, most energetic self.” Momo’s stiffness when standing up or laying down was gone, and she was back to standing at attention when she heard her leash come out!
According to Dr. Menicucci, Wuffes stands out with the most important ingredients for joint health at effective dosages, in a form that dogs actually want to eat. Wuffes offers customized doses depending on your dog’s weight:
- Glucosamine, Chondroitin, and MSM: Essential to support cartilage, reduce inflammation, and maintain connective tissue. Dr. Menicucci explains, “these three support all components of joints that degrade with age.”
- Hyaluronic Acid: Lubricates joints, for smoother movement and improved flexibility.
- Green-Lipped Mussels (GLM): Natural source of anti-inflammatory and antioxidant compounds for mobility.
- Omega-3 Fish Oil, Vitamin C, and Yucca: Provide additional anti-inflammatory support.
- Palability: Momo ate her natural pork liver and honey flavored chew like a treat.
Most supplements are a one-size-fits-all solution with just 1-2 beneficial compounds. Wuffes delivers a full panel of key joint health ingredients - dosed specifically for your dog’s breed, age, and weight - with no artificial flavors or fillers.
#2 Pet Honesty Hip & Joint Health
Rating: 6.7/10
Missing Key Joint Lubricants, but Quality Ingredients
Pet Honesty is a newcomer brand focusing on “cleaner” ingredients - but trails behind on nutrients and dosage.
This formula contains glucosamine, MSM, and chondroitin - important for cartilage, connective tissue, and reducing joint inflammation. But Pet Honesty lacks hyaluronic acid and green-lipped mussels - two anti-inflammatory ingredients crucial for joint lubrication, flexibility, and range of motion.4,5 It also underdoses - particularly on MSM.
#3 PetLab Co. Joint Care Chews
Rating: 5.3/10
Incomplete and expensive
PetLab Co. comes in cute bone-shaped chews. But behind the fun shape is a formula that lacks crucial ingredients for joint health.
PetLab Co. contains glucosamine and green-lipped mussels. But the formula omits critical ingredients: MSM, chondroitin, and hyaluronic acid. MSM and chondroitin help maintain necessary components of joints like cartilage and connective tissue, while hyaluronic acid lubricates joints to improve range of motion.4,6 Their absence means little support for connective tissue, cartilage integrity, and joint lubrication.
The Customer Digest Recommends: Wuffes Advanced Hip & Joint Support
Our Overall Top Pick on ingredients, dosing, and effectiveness is Wuffes Advanced Hip & Joint Support.
Dr. Menicucci (DVM) agrees: “I recommend Wuffes with its comprehensive blend of joint health ingredients to support the structural integrity of joints and alleviate discomfort.”
